（1）基于病毒样颗粒的肿瘤免疫治疗

（2）体外诊断相关的纳米生物技术

（3）新型抗菌、防污材料

（4）仿生微纳米机器人在生物医学中的应用

已主持多项国家自然科学基金项目，并与多家生物医药企业合作开展转化研究；已获授权中国发明专利20余项。曾荣获2022年度厦门大学“田昭武学科交叉奖” （一等奖），2012年度日本陶瓷协会日中陶瓷科学技术交流奖励，2013年厦门市科技进步二等奖。

已授权专利：

1. 任磊，周文博，王苗，李文龙。一种高效促伤口愈合的抗菌水凝胶伤口敷料及其制备方法。专利号：ZL202210452302.7。

2. 聂立铭，陈荣河，任磊。一种具有减脂作用的药用组合物及其应用。专利号：ZL202011181328.X。

3. 任磊，王佳威，李丹阳。一种近红外荧光生物传感器的构建方法和检测方法。专利号：ZL202010059675.9。

4. 任磊，单文俊。重组药物载体蛋白基因及其制备方法与应用。专利号：ZL201710171868.1。

5. 陈志伟，黄建攀，周樨，任磊，程友星。一种碳酸锰纳米复合材料在磁共振成像中的应用。专利号：ZL201710265995.8。

6. 任磊，韩钰，周樨。一种水溶性四氧化三铁纳米粒子的微波合成方法。专利号：ZL201410090607.3。

7. 任磊，周樨，杨安琪。一种表面增强拉曼基底的制备方法。专利号：ZL201410249245.8。

8. 任磊，王东。一种超顺磁性铁氧体纳米粒子的制备方法。专利号：ZL201410089572.1。

9. 任磊，王东。一种上转换荧光/顺磁性双功能纳米晶的制备方法。中国发明专利。专利号：ZL201110303196.8。授权公告号：CN102504820B。授权公告日：2013.9.18。

10. 任磊，王天晓，王军。一种实现肿瘤靶向的非病毒载体的表面修饰方法及其应用。专利号：ZL201110135734.7。

11. 任磊，王军，王林，王俊。一种具有抗感染性的复合组织工程支架材料及其制备方法。专利号：ZL200910112757.9。

12. 任磊，赵阳，王祖勇，张其清。一种用于基因递送的载体的制备方法。专利号：ZL200810071151.0。

13. 任磊，王林，张其清。一种骨/软骨组织工程支架材料及其制备方法。专利号：ZL200810071441.5。

14. 任磊，张其清。一种三维多孔组织工程支架材料及其制备方法。专利号：ZL200410094895.6。

15. 任磊，刘雯，赵雪芹，王军，王俊。一种兼具光敏性和温敏性的纳米水凝胶药物载体材料。专利号：ZL200910112571.3。

16. 张其清，任磊。组织引导再生胶原膜及其制造方法。专利号：ZL94118836.1。

疾病治疗相关：

1. Shan WJ*, Wang CF, Chen HX, and Ren L*. Rational Design of Virus-like Particles for Nanomedicine. ACCOUNT MATERIALS RESEARCH 2023; 4: 814-826.

DOI: 10.1021/accountsmr.3c00050

2. Huang LB, Li LH, Jiang YJ, Cai JF, Cai ST*, Ren YD, Xu HZ, Luo JG, Wang M*, and Ren L*. Tumbler-Inspired Microneedle Containing Robots: Achieving Rapid Self-Orientation and Peristalsis-Resistant Adhesion for Colonic Administration. ADVANCED FUNCTIONAL MATERIALS 2023; 33: 2304276.

DOI: 10.1002/adfm.202304276

3. Zhang Q, Dong JC, Wang JP, Wang JY, Wang CF, Li Y, Chen XL, Wang XM, Shan WJ*, Fu G*, Ren L*. Integration of Protein Nanocage with CpG Motifs: A Virus-Mimicked Core-Shell Nanostructure to Ignite Antitumor Immunity. SMALL 2023; 19: 2301281.

DOI: 10.1002/smll.202301281

4. Guo QY, Wang CF, Zhang Q, Cheng KM, Shan WJ, Wang XM, Yang J, Wang YL, Ren L*. Enhanced cancer immunotherapy by microneedle patch-assisted delivery of HBc VLPs based cancer vaccine. APPLIED MATERIALS TODAY 2021; 24: 101110.

DOI: 10.1016/j.apmt.2021.101110

5. Zhang X, Zhang Y, Zheng HP, He YF, Jia HL, Zhang LJ, Lin CJ, Chen S, Zheng JF, Yang QF, Liu T, Pan XC, Zhang HG, Wang CH*, Ren L*, Shan WJ*. In situ biomimetic nanoformulation for metastatic cancer immunotherapy. ACTA BIOMATERIALIA 2021; 134: 633-648.

DOI: 10.1016/j.actbio.2021.07.055

6. Zhang X, Chen Q, Zhang LY, Zheng HP, Lin CJ, Yang QF, Liu T, Zhang HG, Chen XH, Ren L*, Shan WJ*. Tubule-specific protein nanocages potentiate targeted renal fibrosis therapy. JOURNAL OF NANOBIOTECHNOLOGY 2021; 19:156.

DOI: 10.1186/s12951-021-00900-w

7. Shan WJ, Zheng HP, Fu GF, Liu CF, Li ZZ, Ye YH, Zhao J, Xu D, Sun LP, Wang X, Chen XL, Bi SL, Ren L*, Fu G*. Bioengineered Nanocage from HBc Protein for Combination Cancer Immunotherapy. NANO LETTERS 2019, 19: 1719−1727.

DOI: 10.1021/acs.nanolett.8b04722

8. Song CF, Lin TT, Zhang Q, Thayumanavan S*, Ren L*. pH-Sensitive morphological transitions in polymeric tadpole assemblies for programmed tumor therapy. JOURNAL OF CONTROLLED RELEASE 2019, 293: 1-9.

DOI: 10.1016/j.jconrel.2018.10.033

9. Shan WJ, Chen RH, Zhang Q, Zhao J, Chen BB, Zhou X, Ye SF, Bi SL, Nie LM, Ren L*. Improved Stable Indocyanine Green (ICG)-Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles. ADVANCED MATERIALS 2018, 30: 1707567.

DOI: 10.1002/adma.201707567

10. Cheng KM, Ding YP, Zhao Y, Ye SF, Zhao X, Zhang YL, Ji TJ, Wu HH, Wang B, Anderson GJ, Ren L*, Nie GJ*. Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy. NANO LETTERS 2018; 18: 3250-3258.

DOI: 10.1021/acs.nanolett.8b01071

11. Chen RH, Huang SS, Lin TT, Ma HS, Shan WJ, Duan F, Lv J, Zhang JD, Ren L, Nie LM*. Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes. NATURE NANOTECHNOLOGY 2021; 16: 455-465.

DOI: 10.1038/s41565-020-00844-6

12. Wang JP, Sun JY, Wang YH, Chou TM, Zhang Q, Zhang BL, Ren L*, Wang HJ*. Gold Nanoframeworks with Mesopores for Raman-Photoacoustic Imaging and Photo-Chemo Tumor Therapy in the Second Near-Infrared Biowindow. ADVANCED FUNCTIONAL MATERIALS 2020; 30: 1908825.

DOI: 10.1002/adfm.201908825

13. Zhao J, Ye ZS, Yang J, Zhang Q, Shan WJ, Wang XM, Wang ZX, Ye SF, Zhou X, Shao ZC*, Ren L*. Nanocage encapsulation improves antiepileptic efficiency of phenytoin. BIOMATERIALS 2020; 240: 119849.

DOI: 10.1016/j.biomaterials.2020.119849

14. Yang J, Zhang Q, Liu YX, Zhang XJ, Shan WJ, Ye SF, Zhou X, Ge YL, Wang XM*, Ren L*. Nanoparticle-based co-delivery of siRNA and paclitaxel for dual-targeting of glioblastoma. NANOMEDICINE (LONDON, ENGLAND) 2020, 15: 1391-1409.

DOI: 10.2217/nnm-2020-0066.

15. Zhang Q, Xu D, Guo QY, Shan WJ*, Yang J, Lin TT, Ye SF, Zhou Xi, Ge YL, Bi SL, Ren L*. Theranostic Quercetin Nanoparticle for Treatment of Hepatic Fibrosis. BIOCONJUGATE CHEMISTRY 2019, 30: 2939-2946.

DOI: 10.1021/acs.bioconjchem.9b00631

16. Shan WJ, Chen RH, Zhang Q, Zhao J, Chen BB, Zhou X, Ye SF, Bi SL, Nie LM, Ren L*. Improved Stable Indocyanine Green (ICG)-Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles. ADVANCED MATERIALS 2018, 30: 1707567.

DOI: 10.1002/adma.201707567

17. Cheng KM, Ding YP, Zhao Y, Ye SF, Zhao X, Zhang YL, Ji TJ, Wu HH, Wang B, Anderson GJ, Ren L*, Nie GJ*. Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy. NANO LETTERS 2018; 18: 3250-3258.

DOI: 10.1021/acs.nanolett.8b01071

18. Shan WJ, Zhang DL, Wu YL, Lv XL, Hu B, Zhou X, Ye SF, Bi SL, Ren L*, Zhang XZ*. Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2018; 14: 725-734.

DOI: 10.1016/j.nano.2017.12.002

19. Shen LH, Zhou J, Wang YX, Kang N, Ke XB, Bi SL, and Ren L*. Efficient encapsulation of Fe₃O₄ nanoparticles into genetically engineered hepatitis B core virus-like particles through a specific interaction for potential bioapplications. SMALL 2015; 11: 1190-1196.

DOI: 10.1002/smll.201401952

生物成像与检测相关：

20. Li LH, Zhang JL, Jiao ZQ, Zhou X, Ren L*, and Wang M*. Seamless Integration of Rapid Separation and Ultrasensitive Detection for Complex Biological Samples Using Multistage Annular Functionalized Carbon Nanotube Arrays ADVANCED MATERIALS. 2024: 2312518.

DOI: 10.1002/adma.202312518

21. Chen HX, Zhou T, Li S, Feng JY, Li WL, Li LH, Zhou X, Wang W, Li F, Zhao XQ*, Ren L*. Living Magnetotactic Microrobots Based on Bacteria with a Surface Displayed CRISPR/Cas12a System for Penaeus Viruses Detection. ACS APPLIED MATERIALS & INTERFACES 2023; 15: 47930-47938.

DOI: 10.1021/acsami.3c09690

22. Chen HX, Li BY, Shi SY, Zhou T, Wang XM, Wang ZY, Zhou X, Wang M, Shi W, Ren L*. Au–Fe₃O₄ nanozyme coupled with CRISPR-Cas12a for sensitive and visual antibiotic resistance diagnosing. ANALYTICA CHIMICA ACTA 2023; 1251: 341014.

DOI: 10.1016/j.aca.2023.341014

23. Chen HX, Zhou X, Wang M, Ren L*. Towards Point of Care CRISPR-Based Diagnostics: From Method to Device. JOURNAL OF FUNCTIONAL BIOMATERIALS 2023; 14: 97.

DOI: 10.3390/jfb14020097

24. Li Y, Zhao X, Liu XL, Cheng KM, Han XX, Zhang YL, Min H, Liu GN, Xue JC, Shi J, Qin H, Fan HM*, Ren L*, Nie GJ*. A Bioinspired Nanoprobe with Multilevel Responsive T-1-Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases. ADVANCED MATERIALS 2020, 32: 1906799.

DOI: 10.1002/adma.201906799

25. Wang JW, Hua GP, Li LH, Li DY, Wang FF, Wu JZ, Ye ZY, Zhou X, Ye SF, Yang J, Zhang XJ, Ren L*. Upconversion nanoparticle and gold nanocage satellite assemblies for sensitive ctDNA detection in serum. ANALYST 2020; 145: 5553-5562.

DOI: 10.1039/d0an00701c

26. Zhou X, Ren L*. Building a Better Magnetic Resonance Imaging Contrast Agent Using Macromolecular Architecture. ACS CENTRAL SCIENCE 2017; 3: 820-822.

DOI: 10.1021/acscentsci.7b00308

27. Liu Y, Kang N, Lv J, Zhou ZJ, Zhao QL, Ma LC, Chen Z, Ren L*, Nie LM*. Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites. ADVANCED MATERIALS 2016; 28: 6411-6419.

DOI: 10.1002/adma.201506460

28. Han Y, Lei SL, Lu JH, He Y, Chen ZW*, Ren L*, Zhou X*. Potential use of SERS-assisted theranostic strategy based on Fe₃O₄/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2016; 64: 199-207.

DOI: 10.1016/j.msec.2016.03.090

29. Kang N, Liu Y, Zhou YM, Wang D, Chen C, Ye SF, Nie LM*, Ren L*. Phase and Size Control of Core–Shell Upconversion Nanocrystals Light up Deep Dual Luminescence Imaging and CT In Vivo. ADVANCED HEALTHCARE MATERIALS 2016, 5,1356-1363

DOI: 10.1002/adhm.201600159

抗菌相关：

30. Li WL, Chen HX, Cai JF, Wang M, Zhou X*, and Ren L*. Poly(pentahydropyrimidine)-Based Hybrid Hydrogel with Synergistic Antibacterial and Pro-Angiogenic Ability for the Therapy of Diabetic Foot Ulcers. ADVANCED FUNCTIONAL MATERIALS. 2023; 33: 2303147.

DOI: 10.1002/adfm.202303147

31. Wang YH, Jiao ZQ, Li WL, Zeng S, Deng JL, Wang M*, Ren L*. Superhydrophilic membrane with photo-Fenton self-cleaning property for effective microalgae anti-fouling. CHINESE CHEMICAL LETTERS 2023; 34: 108020

DOI: 10.1016/j.cclet.2022.108020

32. Zeng S, Liu YS, Wang YM, Wang YH, Zhou YM, Li LH, Li S, Zhou X, Wang M, Zhao XQ*, Ren L*. Photo-Fenton self-cleaning carbon fibers membrane supported with Zr-MOF@Fe₂O₃ for effective phosphate removal from algae-rich water. CHEMOSPERE 2023; 323: 138175.

DOI: 10.1016/j.chemosphere.2023.138175

33. Zhou YM, Jiang YJ, Cai JF, Wang JP, Li S, Wang M, Zhou X, Zhao XQ*, Ren L*. A core/shell nanogenerator achieving pH-responsive nitric oxide release for treatment of infected diabetic wounds. NANOSCALE 2022, 14: 14984-14996.

DOI: 10.1039/d2nr03704a

34. Zeng S, Wang YH, Zhou YM, Li WL, Zhou WB, Zhou X, Wang M, Zhao XQ*, Ren L*. Mixed-linker synthesis of L-histidine@zeolitic imidazole framework-8 on amyloid nanofibrils-modified polyacrylonitrile membrane with high separation and antifouling properties. SEPARATION AND PURIFICATION TECHNOLOGY 2022; 290: 120856.

DOI: 10.1016/j.seppur.2022.120856

35. Zhou YM, Chen Z, Zeng S, Wang CF, Li WL, Wang M, Wang XM, Zhou X, Zhao XQ*, Ren L*. Optimization of nanostructured copper sulfide to achieve enhanced enzyme-mimic activities for improving anti-infection performance. ACS APPLIED MATERIALS & INTERFACES 2021, 13: 53659-53670.

DOI: 10.1021/acsami.1c17985

36. Zhou YM, Feng H, Jiang YJ, Hua GP, Zhang Q, Zeng S, Li WL, Li LH, Kang N*, Ren L*. Nanoliquid dressing with enhancing anti-infection performance under the moderate photothermal effect for wound treatment. ACS APPLIED MATERIALS & INTERFACES 2021; 13: 18443-18453.

DOI: 10.1021/acsami.0c21854

37. Li WL, Thian ES, Wang M, Wang ZY*, Ren L*. Surface design for antibacterial materials: from fundamentals to advanced strategies. ADVANCED SCIENCE 2021; 8: 2100368.

DOI: 10.1002/advs.202100368